HCLS1

Across TCGA patient cohorts, HCLS1 RNA expression is significantly associated with the protein abundance of many other proteins, with 21,069 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HCLS1-associated proteins across cancer lineages are PTPN6, PTPN7, and PTPRC. Each is linked with HCLS1 in more than 9 cancer types. Because this analysis shows association rather than direction, both HCLS1-to-partner and partner-to-HCLS1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HCLS1 versus PTPN6 in GBM, with a Pearson correlation of 0.82.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HCLS1→partner) and Y-score (partner→HCLS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PTPN6 →	+0.838	+1.285	<.001	<.001	3	10
GBM	PTPN7 →	+0.599	+1.097	<.001	<.001	3	10
GBM	PTPRC →	+0.932	+1.399	<.001	<.001	3	10
GBM	WAS →	+0.806	+1.381	<.001	<.001	3	10
OV	WIPF1 →	+0.560	+1.045	<.001	<.001	3	10
GBM	CCDC88B_S597 →	+0.751	+1.136	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,069 associations by consensus.

HCLS1 vs PTPN6 — GBM

Explore this scatter interactively →