HCLS1

Across TCGA patient cohorts, HCLS1 mutation is significantly associated with the RNA expression of many other genes, with 1,897 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HCLS1-associated genes across cancer lineages are C16orf95, RPL23AP82, and MTFP1. Each is linked with HCLS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HCLS1-to-partner and partner-to-HCLS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C16orf95 grouped by HCLS1-low versus HCLS1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCLS1→partner) and Y-score (partner→HCLS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	C16orf95 →	+0.313	+2.523	.003	.009	3	3
UCEC	RPL23AP82 →	+0.359	+3.008	.001	<.001	3	3
UCEC	MTFP1 →	+0.477	+1.736	.004	.007	3	3
SKCM	GPR158 →	-0.830	-2.321	.002	.005	3	2
COAD	ATP5F1A →	+0.698	+3.499	<.001	.002	3	2
UCEC	HAUS1 →	+0.464	+2.230	.005	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,897 associations by consensus.

C16orf95 by HCLS1 expression — SKCM

Explore this box plot interactively →