HCLS1

Across TCGA patient cohorts, HCLS1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. COAD shows the largest number of these associations.

The most reproducible HCLS1-associated genes across cancer lineages are ASNS, eEF2, and Cyclin-B1. Each is linked with HCLS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HCLS1-to-partner and partner-to-HCLS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by HCLS1-low versus HCLS1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCLS1→partner) and Y-score (partner→HCLS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.615	+3.330	<.001	.005	3	3
COAD	eEF2 →	+0.328	+2.178	.018	.035	3	2
UCEC	Cyclin-B1 →	+0.453	+1.678	.035	.023	3	2
COAD	FASN →	+0.411	+2.178	.025	.035	3	1
COAD	GAPDH →	+0.808	+2.182	<.001	.033	2	2
COAD	MIG-6 →	+0.113	+3.381	.014	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

ASNS by HCLS1 expression — COAD

Explore this box plot interactively →