HCLS1

Across TCGA cell cohorts, HCLS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,686 significant associations in total. BONE shows the largest number of these associations.

The most reproducible HCLS1-associated GO terms across cancer lineages are DNA damage checkpoint signaling, Positive regulation of mRNA metabolic process, and Regulation of stem cell population maintenance. Each is linked with HCLS1 in more than 7 cancer types. Because this analysis shows association rather than direction, both HCLS1-to-partner and partner-to-HCLS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA damage checkpoint signaling grouped by HCLS1-low versus HCLS1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HCLS1→partner) and Y-score (partner→HCLS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA damage checkpoint signaling →	+0.071	+2.584	.006	.006	3	8
OESOPHAGUS	Positive regulation of mRNA metabolic process →	+0.058	+2.947	.004	.002	3	8
PANCREAS	Regulation of stem cell population maintenance →	+0.041	+1.696	.008	.008	2	7
BONE	Nuclear export →	+0.081	+3.039	<.001	<.001	3	6
BLOOD_Lymphoma	Protein destabilization →	+0.058	+2.160	<.001	<.001	3	6
STOMACH	Positive regulation of DNA-templated transcription, elongation →	+0.049	+1.277	.005	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,686 associations by consensus.

DNA damage checkpoint signaling by HCLS1 expression — BONE

Explore this box plot interactively →