HCG25

Across TCGA pan-cancer cohorts, HCG25 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated HCG25 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HCG25 RNA is associated with better overall survival. In most high-consensus cancer types, elevated HCG25 expression acts as an unfavorable survival marker, although some lineages such as HNSC and READ show a favorable association.

HNSC, KIRC, and ACC are the cancer types where HCG25 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	II,III,IV	0.549	0.340	.002	86	view →
KIRC	OS	Median	All	0.555	0.698	<.001	58	view →
ACC	DFS	Median	All	0.431	0.723	<.001	56	view →
LIHC	DFS	Median	All	0.441	0.657	<.001	53	view →
COAD	OS	Quartile	III,IV	0.218	0.831	.001	52	view →
KICH	OS	Median	II,III,IV	0.773	1.000	.009	50	view →
UVM	DFS	Median	III,IV	0.200	0.892	.001	32	view →
READ	OS	Median	II,III,IV	0.861	0.457	.005	31	view →
LUSC	OS	Quartile	All	0.821	0.682	.006	26	view →
THCA	OS	Median	All	0.955	0.991	.003	26	view →
LUAD	OS	Quartile	II,III,IV	0.607	0.320	.002	24	view →
PAAD	OS	Quartile	All	0.712	0.339	.007	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

HCG25–HNSC (OS)

Open the HNSC breakdown →