HCG21

Across TCGA patient cohorts, HCG21 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,097 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible HCG21-associated GO terms across cancer lineages are Tumor necrosis factor-mediated signaling pathway, Lysosomal lumen acidification, and Regulation of dendritic cell differentiation. Each is linked with HCG21 in more than 14 cancer types. Because this analysis shows association rather than direction, both HCG21-to-partner and partner-to-HCG21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tumor necrosis factor-mediated signaling pathway grouped by HCG21-low versus HCG21-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HCG21→partner) and Y-score (partner→HCG21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Tumor necrosis factor-mediated signaling pathway →	+0.056	+0.449	<.001	<.001	3	15
STAD	Lysosomal lumen acidification →	+0.057	+0.377	<.001	<.001	3	15
ESCA	Regulation of dendritic cell differentiation →	+0.103	+0.360	<.001	<.001	3	14
STAD	Proton motive force-driven ATP synthesis →	+0.066	+0.444	<.001	<.001	3	14
STAD	Protein processing →	+0.037	+0.323	<.001	<.001	3	14
STAD	Respiratory electron transport chain →	+0.049	+0.350	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,097 associations by consensus.

Tumor necrosis factor-mediated signaling pathway by HCG21 expression — STAD

Explore this box plot interactively →