HCG17

Across TCGA patient cohorts, HCG17 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HCG17-associated genes across cancer lineages are MEK1, PRDX1, and eEF2. Each is linked with HCG17 in more than 1 cancer types. Because this analysis shows association rather than direction, both HCG17-to-partner and partner-to-HCG17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by HCG17-low versus HCG17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCG17→partner) and Y-score (partner→HCG17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.498	+3.584	.002	.002	3	2
UCEC	PRDX1 →	+0.211	+2.321	.023	.034	3	2
UCEC	eEF2 →	+0.489	+3.169	.002	.018	3	1
UCEC	eIF4G →	+0.368	+2.459	.008	.019	3	1
UCEC	ERK2 →	+0.284	+3.169	.001	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.128	-2.575	.022	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

MEK1 by HCG17 expression — UCEC

Explore this box plot interactively →