Across TCGA pan-cancer cohorts, HCG14 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of HCG14’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HCG14 RNA is repressed in tumor relative to normal tissue. In most cancer types HCG14 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.
KIRC, KICH, and THCA are the cancer types where HCG14 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HCG14 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.