HCFC2

Across TCGA cell cohorts, HCFC2 mutation is significantly associated with the RNA expression of many other genes, with 443 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HCFC2-associated genes across cancer lineages are C20orf85, PAX1, and C5orf49. Each is linked with HCFC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HCFC2-to-partner and partner-to-HCFC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C20orf85 grouped by HCFC2-low versus HCFC2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCFC2→partner) and Y-score (partner→HCFC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C20orf85 →	+0.015	+3.969	.005	.009	3	1
BLOOD_Leukemia	PAX1 →	+0.038	+3.475	<.001	.006	3	1
BLOOD_Leukemia	C5orf49 →	+0.040	+4.889	<.001	<.001	3	1
BLOOD_Leukemia	SMIM32 →	+0.036	+4.584	<.001	.001	3	1
BLOOD_Leukemia	CNTNAP3C →	+0.157	+3.729	<.001	.009	3	1
BLOOD_Leukemia	KCNK2 →	+0.117	+3.533	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 443 associations by consensus.

C20orf85 by HCFC2 expression — BLOOD_Leukemia

Explore this box plot interactively →