HCFC1R1

Across TCGA pan-cancer cohorts, HCFC1R1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of HCFC1R1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where HCFC1R1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HCFC1R1 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

KIRP, KIRC, and HNSC are the cancer types where HCFC1R1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HCFC1R1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	+1.606	<.001	11	view →
KIRC	Female	All	+1.030	<.001	11	view →
HNSC	All	III,IV	+0.735	<.001	11	view →
LIHC	Female	II,III,IV	+1.416	<.001	9	view →
THCA	Male	III,IV	+0.765	<.001	9	view →
KICH	Female	II,III,IV	−1.790	<.001	8	view →
UCEC	All	All	−0.708	<.001	6	view →
BRCA	All	III,IV	+0.666	<.001	6	view →
CHOL	All	All	+2.145	<.001	3	view →
BLCA	Male	III,IV	−1.084	.019	3	view →
READ	Female	All	−0.961	.013	2	view →
PRAD	All	All	−0.527	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

HCFC1R1–KIRP

Open the KIRP breakdown →