HCFC1

Across TCGA pan-cancer cohorts, HCFC1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated HCFC1 data layer compared with 24 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher HCFC1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HCFC1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and COAD show a favorable association.

LUAD, COAD, and HNSC are the cancer types where HCFC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.764	0.507	.004	26	view →
COAD	DFS	Median	All	1.000	0.922	.017	24	view →
HNSC	DFS	Quartile	IV	0.516	0.871	.007	21	view →
CCRCC	OS	Tertile	All	0.930	0.740	.023	20	view →
GBM	OS	Quartile	All	0.554	0.266	.002	10	view →
PDAC	DFS	Quartile	All	0.948	0.708	.011	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

HCFC1–LUAD (DFS)

Open the LUAD breakdown →