HCFC1

Across TCGA patient cohorts, HCFC1 mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HCFC1-associated genes across cancer lineages are eEF2, Caspase-7-cleavedD198, and Collagen-VI. Each is linked with HCFC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HCFC1-to-partner and partner-to-HCFC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by HCFC1-low versus HCFC1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCFC1→partner) and Y-score (partner→HCFC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	eEF2 →	+0.279	+1.700	.015	.042	3	3
STAD	Caspase-7-cleavedD198 →	+0.738	+1.874	.009	.048	3	3
STAD	Collagen-VI →	-0.251	-3.000	.016	.033	3	3
UCEC	Notch1 →	+0.069	+0.948	.049	.049	3	3
UCEC	p53 →	-0.257	-1.765	.008	.011	3	3
UCEC	p62 Lck ligand →	+0.270	+1.710	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

eEF2 by HCFC1 expression — STAD

Explore this box plot interactively →