HCFC1

Across TCGA cell cohorts, HCFC1 mutation is significantly associated with the mutation status of many other genes, with 7,550 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HCFC1-associated genes across cancer lineages are LYST, LIG3, and COL6A3. Each is linked with HCFC1 in more than 5 cancer types. Because this analysis shows association rather than direction, both HCFC1-to-partner and partner-to-HCFC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYST grouped by HCFC1-low versus HCFC1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCFC1→partner) and Y-score (partner→HCFC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LYST →	+2.188	+3.154	<.001	<.001	1	6
UPPER_AERODIGESTIVE_TRACT	LIG3 →	+4.392	+4.954	.008	.008	1	5
BLOOD_Leukemia	COL6A3 →	+1.714	+2.211	<.001	<.001	1	5
BLOOD_Leukemia	SVEP1 →	+2.833	+2.678	<.001	<.001	1	5
LUNG_NSCLC_LUAD	DNAH10 →	+2.478	+3.544	.001	.001	1	5
BLOOD_Leukemia	MGA →	+2.640	+2.879	<.001	<.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,550 associations by consensus.

LYST by HCFC1 expression — LARGE_INTESTINE

Explore this box plot interactively →