HCFC1-AS1

Across TCGA pan-cancer cohorts, HCFC1-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated HCFC1-AS1 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher HCFC1-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated HCFC1-AS1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

SKCM, HNSC, and KIRP are the cancer types where HCFC1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.394	0.273	<.001	117	view →
HNSC	DFS	Quartile	All	0.723	0.529	<.001	90	view →
KIRP	DFS	Quartile	III,IV	0.472	0.793	.001	56	view →
LUAD	OS	Tertile	II,III,IV	0.747	0.452	.002	47	view →
THCA	OS	Tertile	II,III,IV	0.945	0.993	.001	41	view →
SARC	DFS	Median	All	0.592	0.429	.002	32	view →
CHOL	DFS	Quartile	All	0.708	0.218	.006	30	view →
PCPG	DFS	Quartile	All	0.978	0.765	.006	22	view →
LGG	OS	Quartile	All	0.722	0.894	<.001	18	view →
UVM	OS	Tertile	All	0.578	0.884	.012	15	view →
THYM	OS	Median	All	0.967	0.733	.003	14	view →
READ	OS	Median	All	0.763	0.958	.012	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

HCFC1-AS1–SKCM (OS)

Open the SKCM breakdown →