HCCS

Across TCGA pan-cancer cohorts, HCCS mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HCCS data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher HCCS mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HCCS expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

COAD, HNSC, and PDAC are the cancer types where HCCS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	All	1.000	0.822	.035	54	view →
HNSC	OS	Median	III,IV	0.544	0.798	.008	8	view →
PDAC	DFS	Tertile	IV	0.550	0.217	.024	3	view →
LUAD	OS	Median	III,IV	0.861	0.375	.023	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

HCCS–COAD (DFS)

Open the COAD breakdown →