HCCS

Across TCGA patient cohorts, HCCS RNA expression is significantly associated with the mutation status of many other genes, with 10,393 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HCCS-associated genes across cancer lineages are TP53, FAT3, and TTN. Each is linked with HCCS in more than 9 cancer types. Because this analysis shows association rather than direction, both HCCS-to-partner and partner-to-HCCS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TP53 grouped by HCCS-low versus HCCS-high in PRAD.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCCS→partner) and Y-score (partner→HCCS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PRAD	TP53 →	+2.217	+0.249	.001	<.001	2	10
BRCA	FAT3 →	+2.295	+0.314	.001	<.001	3	6
OV	TTN →	+1.745	+0.268	<.001	.001	3	5
UCEC	PLEKHH2 →	+2.176	+0.452	<.001	<.001	3	5
UCEC	LRP1B →	+1.436	+0.273	<.001	<.001	3	5
SKCM	APC →	+1.957	+0.374	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,393 associations by consensus.

TP53 by HCCS expression — PRAD

Explore this box plot interactively →