HCCS

Across TCGA patient cohorts, HCCS protein abundance is significantly associated with the RNA expression of many other genes, with 12,357 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible HCCS-associated genes across cancer lineages are SPARCL1, TIMP3, and SLC35A2. Each is linked with HCCS in more than 6 cancer types. Because this analysis shows association rather than direction, both HCCS-to-partner and partner-to-HCCS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HCCS versus SPARCL1 in UCEC, with a Pearson correlation of -0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCCS→partner) and Y-score (partner→HCCS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SPARCL1 →	-1.127	-0.247	<.001	<.001	3	7
OV	TIMP3 →	-1.462	-0.303	<.001	<.001	3	6
LSCC	SLC35A2 →	+0.582	+0.287	<.001	<.001	3	6
COAD	PMP22 →	-0.749	-0.290	<.001	.003	3	6
UCEC	CNRIP1 →	-0.828	-0.332	.001	<.001	2	7
OV	FZD1 →	-0.893	-0.270	<.001	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,357 associations by consensus.

HCCS vs SPARCL1 — UCEC

Explore this scatter interactively →