HCCS

Across TCGA patient cohorts, HCCS mutation is significantly associated with the immune_cell of many other genes, with 2 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible HCCS-associated genes across cancer lineages are CD8+ T-cells and CD8+ Tcm. Each is linked with HCCS in more than 1 cancer types. Because this analysis shows association rather than direction, both HCCS-to-partner and partner-to-HCCS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ T-cells grouped by HCCS-low versus HCCS-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCCS→partner) and Y-score (partner→HCCS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CD8+ T-cells →	+0.078	+4.373	<.001	.021	3	2
BRCA	CD8+ Tcm →	+0.158	+3.825	<.001	.041	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

CD8+ T-cells by HCCS expression — BRCA

Explore this box plot interactively →