HCCS

Across TCGA cell cohorts, HCCS RNA expression is significantly associated with the go_rna of many other GO terms, with 3,807 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HCCS-associated GO terms across cancer lineages are Peptidyl-proline modification, Positive regulation of mitotic cytokinesis, and Regulation of anaphase-promoting complex-dependent catabolic process. Each is linked with HCCS in more than 10 cancer types. Because this analysis shows association rather than direction, both HCCS-to-partner and partner-to-HCCS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Peptidyl-proline modification grouped by HCCS-low versus HCCS-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HCCS→partner) and Y-score (partner→HCCS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Peptidyl-proline modification →	+0.136	+0.731	.001	<.001	3	11
CNS	Positive regulation of mitotic cytokinesis →	+0.124	+0.682	<.001	<.001	3	11
PANCREAS	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.105	+0.640	<.001	<.001	3	11
PANCREAS	Mitotic nuclear division →	+0.072	+0.637	.001	.004	3	10
LUNG_NSCLC_LUSC	Growth hormone secretion →	+0.143	+1.217	.003	<.001	2	11
LUNG_NSCLC_LUSC	Negative regulation of hippo signaling →	+0.112	+0.992	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,807 associations by consensus.

Peptidyl-proline modification by HCCS expression — PANCREAS

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