HCCAT5

Across TCGA pan-cancer cohorts, HCCAT5 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated HCCAT5 data layer compared with 18 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher HCCAT5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HCCAT5 expression acts as an unfavorable survival marker.

SKCM and BLCA are the cancer types where HCCAT5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	III,IV	0.138	0.841	<.001	20	view →
BLCA	DFS	Median	All	0.174	0.625	.023	12	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

HCCAT5–SKCM (OS)

Open the SKCM breakdown →