HCAR2

Across TCGA patient cohorts, HCAR2 protein abundance is significantly associated with the RNA expression of many other genes, with 2,292 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HCAR2-associated genes across cancer lineages are SPAG16, F8, and CYRIA. Each is linked with HCAR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HCAR2-to-partner and partner-to-HCAR2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HCAR2 versus SPAG16 in LUAD, with a Pearson correlation of -0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCAR2→partner) and Y-score (partner→HCAR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SPAG16 →	-0.672	-0.766	<.001	.009	3	2
LUAD	F8 →	-0.708	-0.671	.003	.004	3	2
LUAD	CYRIA →	-0.607	-0.627	.003	.009	3	2
HNSC	ENPP5 →	-1.342	-0.891	.004	.003	3	2
HNSC	ZNF346 →	-0.577	-1.121	.004	.002	3	2
HNSC	MCF2L →	-0.952	-1.054	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,292 associations by consensus.

HCAR2 vs SPAG16 — LUAD

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