HCAR2

Across TCGA patient cohorts, HCAR2 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HCAR2-associated genes across cancer lineages are JNK2, STAT5a, and ATM. Each is linked with HCAR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HCAR2-to-partner and partner-to-HCAR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by HCAR2-low versus HCAR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCAR2→partner) and Y-score (partner→HCAR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.211	+1.584	.006	.036	3	1
UCEC	STAT5a →	+0.309	+1.584	.049	.036	3	1
UCEC	ATM →	-0.465	-1.584	.009	.036	3	1
UCEC	Chk2 →	-0.209	-1.584	.023	.036	3	1
SKCM	Snail →	+0.238	+2.820	.010	.035	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

JNK2 by HCAR2 expression — UCEC

Explore this box plot interactively →