HCAR2

Across TCGA cell cohorts, HCAR2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,616 significant associations in total. URINARY_TRACT shows the largest number of these associations.

The most reproducible HCAR2-associated GO terms across cancer lineages are NMDA selective glutamate receptor signaling pathway, Cell-substrate junction organization, and Cell-substrate junction assembly. Each is linked with HCAR2 in more than 9 cancer types. Because this analysis shows association rather than direction, both HCAR2-to-partner and partner-to-HCAR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NMDA selective glutamate receptor signaling pathway grouped by HCAR2-low versus HCAR2-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HCAR2→partner) and Y-score (partner→HCAR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	NMDA selective glutamate receptor signaling pathway →	+0.294	+3.137	<.001	<.001	3	10
URINARY_TRACT	Cell-substrate junction organization →	+0.137	+2.633	<.001	<.001	3	8
PANCREAS	Cell-substrate junction assembly →	+0.160	+1.265	<.001	.003	3	8
OESOPHAGUS	Regulation of tumor necrosis factor-mediated signaling pathway →	+0.113	+2.902	<.001	.004	3	8
PANCREAS	Positive regulation of protein import into nucleus →	+0.111	+1.538	<.001	.001	3	8
BONE	Negative regulation of DNA-templated transcription initiation →	+0.121	+0.732	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,616 associations by consensus.

NMDA selective glutamate receptor signaling pathway by HCAR2 expression — URINARY_TRACT

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