HCAR2

Across TCGA cell cohorts, HCAR2 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HCAR2-associated genes across cancer lineages are MAJIN, KLHL34, and LCE1B. Each is linked with HCAR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HCAR2-to-partner and partner-to-HCAR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAJIN grouped by HCAR2-low versus HCAR2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCAR2→partner) and Y-score (partner→HCAR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAJIN →	+0.111	+3.554	<.001	.007	3	1
LARGE_INTESTINE	KLHL34 →	+0.097	+4.115	.002	.001	3	1
LARGE_INTESTINE	LCE1B →	+0.123	+3.878	.004	.003	3	1
LARGE_INTESTINE	ELOA3CP →	+0.112	+3.509	.007	.008	3	1
OVARY	BPIFA3 →	+0.020	+5.807	<.001	.001	3	1
OVARY	OR8K3 →	+0.035	+5.196	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MAJIN by HCAR2 expression — LARGE_INTESTINE

Explore this box plot interactively →