Across TCGA patient cohorts, HCAR1 mutation is significantly associated with the RNA expression of many other genes, with 539 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HCAR1-associated genes across cancer lineages are MIR7845, PCNPP2, and RNA5SP457. Each is linked with HCAR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HCAR1-to-partner and partner-to-HCAR1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCAR1→partner) and Y-score (partner→HCAR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR7845 →	+0.462	+3.864	<.001	.001	3	2
LUAD	PCNPP2 →	+0.117	+7.333	<.001	<.001	3	2
BLCA	RNA5SP457 →	+0.440	+4.758	<.001	.003	3	2
BRCA	GAPDHP19 →	+0.074	+5.020	<.001	.009	3	2
UCEC	RNA5SP410 →	+0.507	+2.374	.007	.004	3	2
UCEC	LINC01895 →	+0.260	+2.166	.005	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 539 associations by consensus.

Exploration

HCAR1 survival (RNA) · tumor vs normal (RNA) · all HCAR1 data types