Across TCGA cell cohorts, HCAR1 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HCAR1-associated genes across cancer lineages are NEUROD4, OR10R2, and CSN2. Each is linked with HCAR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HCAR1-to-partner and partner-to-HCAR1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCAR1→partner) and Y-score (partner→HCAR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NEUROD4 →	+0.022	+4.977	<.001	.007	3	1
LARGE_INTESTINE	OR10R2 →	+0.027	+4.977	<.001	.007	3	1
BREAST	CSN2 →	+0.042	+5.169	<.001	.005	3	1
BLOOD_Leukemia	OR10H2 →	+0.018	+3.969	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

HCAR1 survival (RNA) · tumor vs normal (RNA) · all HCAR1 data types