HBS1L

Across TCGA pan-cancer cohorts, HBS1L Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HBS1L data layer compared with 28 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher HBS1L Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated HBS1L expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, MESO, and COAD are the cancer types where HBS1L Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.949	0.618	.006	22	view →
MESO	DFS	Median	III,IV	0.078	0.376	.012	9	view →
COAD	OS	Median	II,III,IV	0.630	0.853	.022	4	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

HBS1L–UCEC (DFS)

Open the UCEC breakdown →