HBS1L

Across TCGA pan-cancer cohorts, HBS1L mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HBS1L data layer compared with 28 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher HBS1L mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HBS1L expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

CCRCC, PDAC, and LSCC are the cancer types where HBS1L mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.504	0.978	.004	11	view →
PDAC	DFS	Quartile	All	0.310	0.580	.023	5	view →
LSCC	OS	Median	II,III,IV	1.000	0.907	.027	2	view →
GBM	DFS	Median	All	0.824	0.679	.033	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

HBS1L–CCRCC (DFS)

Open the CCRCC breakdown →