HBS1L

Across TCGA patient cohorts, HBS1L protein abundance is significantly associated with the RNA expression of many other genes, with 6,196 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible HBS1L-associated genes across cancer lineages are MRPL18, SFT2D1, and TRMT11. Each is linked with HBS1L in more than 6 cancer types. Because this analysis shows association rather than direction, both HBS1L-to-partner and partner-to-HBS1L results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HBS1L versus MRPL18 in BRCA, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HBS1L→partner) and Y-score (partner→HBS1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MRPL18 →	+0.603	+0.313	<.001	<.001	3	7
OV	SFT2D1 →	+0.614	+0.473	.006	.006	3	7
OV	TRMT11 →	+0.716	+0.724	.001	<.001	3	7
BRCA	PDCD2 →	+0.600	+0.337	<.001	<.001	3	7
OV	VTA1 →	+0.774	+0.638	<.001	<.001	3	7
OV	HDDC2 →	+0.673	+0.704	.003	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,196 associations by consensus.

HBS1L vs MRPL18 — BRCA

Explore this scatter interactively →