HBS1L

Across TCGA patient cohorts, HBS1L mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HBS1L-associated genes across cancer lineages are PDCD4, EGFR_pY1068, and 14-3-3_epsilon. Each is linked with HBS1L in more than 1 cancer types. Because this analysis shows association rather than direction, both HBS1L-to-partner and partner-to-HBS1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by HBS1L-low versus HBS1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HBS1L→partner) and Y-score (partner→HBS1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.390	-1.807	.010	.024	3	2
UCEC	EGFR_pY1068 →	-0.289	-2.000	<.001	<.001	3	2
COAD	14-3-3_epsilon →	+0.156	+2.824	.006	.034	3	1
COAD	PREX1 →	+0.221	+2.347	.018	.019	3	1
COAD	Caspase-7-cleavedD198 →	+0.940	+2.330	.008	.020	2	2
UCEC	14-3-3_beta →	-0.077	-2.673	.018	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

PDCD4 by HBS1L expression — UCEC

Explore this box plot interactively →