HBS1L

Across TCGA cell cohorts, HBS1L mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HBS1L-associated genes across cancer lineages are OR10W1, CST9, and PRND. Each is linked with HBS1L in more than 1 cancer types. Because this analysis shows association rather than direction, both HBS1L-to-partner and partner-to-HBS1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10W1 grouped by HBS1L-low versus HBS1L-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HBS1L→partner) and Y-score (partner→HBS1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR10W1 →	+0.008	+3.240	.001	.004	3	1
LARGE_INTESTINE	CST9 →	+0.044	+3.029	.001	.003	3	1
BLOOD_Leukemia	PRND →	+0.006	+4.874	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

OR10W1 by HBS1L expression — LARGE_INTESTINE

Explore this box plot interactively →