HBQ1

Across TCGA pan-cancer cohorts, HBQ1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HBQ1 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher HBQ1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HBQ1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where HBQ1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.911	0.575	<.001	28	view →
PDAC	DFS	Quartile	II,III,IV	0.304	0.670	<.001	18	view →
HNSC	DFS	Quartile	All	0.775	0.558	.038	1	view →
LUAD	DFS	Median	All	0.897	0.698	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

HBQ1–CCRCC (DFS)

Open the CCRCC breakdown →