HBQ1

Across TCGA patient cohorts, HBQ1 protein abundance is significantly associated with the RNA expression of many other genes, with 4,214 significant associations in total. OV shows the largest number of these associations.

The most reproducible HBQ1-associated genes across cancer lineages are HBB, HBA1, and PF4. Each is linked with HBQ1 in more than 8 cancer types. Because this analysis shows association rather than direction, both HBQ1-to-partner and partner-to-HBQ1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HBQ1 versus HBB in GBM, with a Pearson correlation of 0.75.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HBQ1→partner) and Y-score (partner→HBQ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HBB →	+1.944	+0.831	<.001	<.001	3	9
GBM	HBA1 →	+1.877	+0.868	<.001	<.001	3	8
GBM	PF4 →	+0.986	+0.744	<.001	<.001	3	7
GBM	HBA2 →	+2.016	+0.876	<.001	<.001	3	7
PDAC	FOSB →	+1.785	+0.966	<.001	<.001	3	5
CCRCC	HEMGN →	+0.559	+0.792	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,214 associations by consensus.

HBQ1 vs HBB — GBM

Explore this scatter interactively →