HBQ1

Across TCGA patient cohorts, HBQ1 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HBQ1-associated genes across cancer lineages are MIR3133, RN7SL44P, and MIR3678. Each is linked with HBQ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HBQ1-to-partner and partner-to-HBQ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3133 grouped by HBQ1-low versus HBQ1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HBQ1→partner) and Y-score (partner→HBQ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR3133 →	+0.560	+5.133	.001	.008	3	1
UCEC	RN7SL44P →	+0.234	+5.031	.009	.009	3	1
UCEC	MIR3678 →	+0.460	+5.186	.008	.007	3	1
COAD	RNU105C →	+0.427	+7.741	<.001	.009	3	1
UCEC	RNU6-1026P →	+0.738	+5.937	<.001	.002	3	1
UCEC	ZNF705CP →	+0.102	+5.484	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MIR3133 by HBQ1 expression — UCEC

Explore this box plot interactively →