HBP1

Across TCGA pan-cancer cohorts, HBP1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated HBP1 data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher HBP1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated HBP1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

UCEC, LSCC, and GBM are the cancer types where HBP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	0.311	1.000	.001	14	view →
LSCC	OS	Quartile	II,III,IV	0.927	0.585	.024	8	view →
GBM	OS	Median	All	0.752	0.960	.017	3	view →
LUAD	DFS	Median	III,IV	0.432	0.925	.047	3	view →
CCRCC	OS	Median	IV	1.000	0.162	.041	2	view →
HNSC	DFS	Median	All	0.583	0.775	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

HBP1–UCEC (OS)

Open the UCEC breakdown →