HBP1

Across TCGA patient cohorts, HBP1 mutation is significantly associated with the RNA expression of many other genes, with 1,039 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HBP1-associated genes across cancer lineages are MIR4752, MIR4287, and FAT1P1. Each is linked with HBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HBP1-to-partner and partner-to-HBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4752 grouped by HBP1-low versus HBP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HBP1→partner) and Y-score (partner→HBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR4752 →	+0.086	+4.481	<.001	.002	3	2
UCEC	MIR4287 →	+0.150	+3.306	<.001	.003	3	2
SKCM	FAT1P1 →	+0.085	+4.771	<.001	<.001	3	2
HNSC	E2F6P1 →	+0.036	+5.178	<.001	.002	3	2
HNSC	RN7SL470P →	+0.163	+3.847	<.001	.006	3	2
UCEC	TRAJ11 →	+0.384	+1.643	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,039 associations by consensus.

MIR4752 by HBP1 expression — UCEC

Explore this box plot interactively →