HBP1

Across TCGA patient cohorts, HBP1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HBP1-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and eIF4E. Each is linked with HBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HBP1-to-partner and partner-to-HBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by HBP1-low versus HBP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HBP1→partner) and Y-score (partner→HBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.106	-1.401	.004	.046	3	2
UCEC	EGFR_pY1068 →	-0.244	-2.000	.009	.030	3	1
UCEC	eIF4E →	+0.163	+3.183	.040	.009	3	1
UCEC	JNK_pT183_Y185 →	-0.184	-1.752	.003	.014	3	1
UCEC	JNK2 →	+0.278	+2.169	<.001	.003	3	1
UCEC	Ku80 →	+0.307	+1.778	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

14-3-3_beta by HBP1 expression — UCEC

Explore this box plot interactively →