Across TCGA patient cohorts, HBM protein abundance is significantly associated with the RNA expression of many other genes, with 1,776 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HBM-associated genes across cancer lineages are HBB, HBA1, and HBA2. Each is linked with HBM in more than 7 cancer types. Because this analysis shows association rather than direction, both HBM-to-partner and partner-to-HBM results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HBM→partner) and Y-score (partner→HBM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	HBB →	+2.196	+0.725	.003	.007	3	8
GBM	HBA1 →	+1.645	+0.802	<.001	<.001	3	7
PDAC	HBA2 →	+1.975	+0.796	.002	.002	2	7
CCRCC	ALAS2 →	+1.202	+1.129	<.001	<.001	3	5
CCRCC	HEMGN →	+0.975	+1.587	<.001	<.001	3	4
GBM	PF4 →	+0.772	+0.616	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,776 associations by consensus.

Exploration

HBM survival (RNA) · tumor vs normal (RNA) · all HBM data types