Across TCGA pan-cancer cohorts, HBG2 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of HBG2’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where HBG2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types HBG2 is over-expressed in tumor, although a few such as COAD and LSCC show the opposite, repressed pattern.
COAD, LSCC, and HNSC are the cancer types where HBG2 tumor–normal differential expression is most reproducible.
mass-spec protein tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HBG2 mass-spec protein (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.