Across TCGA patient cohorts, HBG2 mutation is significantly associated with the RNA expression of many other genes, with 208 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible HBG2-associated genes across cancer lineages are RNU1-17P, OR4F4, and ORC1P1. Each is linked with HBG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HBG2-to-partner and partner-to-HBG2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HBG2→partner) and Y-score (partner→HBG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	RNU1-17P →	+0.432	+5.068	<.001	.008	3	2
LGG	OR4F4 →	+0.039	+7.977	<.001	.007	3	2
LUSC	ORC1P1 →	+0.177	+5.625	<.001	.004	3	2
UCEC	MIR4482 →	+1.067	+3.637	.002	.003	3	2
UCEC	HSPE1-MOB4 →	+0.224	+3.021	<.001	.004	3	1
HNSC	MIR302D →	+0.889	+5.069	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 208 associations by consensus.

Exploration

HBG2 survival (RNA) · tumor vs normal (RNA) · all HBG2 data types