Across TCGA patient cohorts, HBG2 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible HBG2-associated genes across cancer lineages are eIF4E, eEF2, and HER2_pY1248. Each is linked with HBG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HBG2-to-partner and partner-to-HBG2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HBG2→partner) and Y-score (partner→HBG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.267	+3.000	.028	.037	2	2
SKCM	eEF2 →	+0.304	+3.321	.039	.009	3	1
SKCM	HER2_pY1248 →	-0.151	-2.309	.020	.033	3	1
SKCM	JNK_pT183_Y185 →	-0.199	-2.459	.001	.018	3	1
SKCM	p27 →	-0.185	-2.000	.022	.031	3	1
SKCM	Rad50 →	+0.552	+2.182	<.001	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

HBG2 survival (RNA) · tumor vs normal (RNA) · all HBG2 data types