Across TCGA pan-cancer cohorts, HBG1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HBG1 data layer compared with 16 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher HBG1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HBG1 expression acts as an unfavorable survival marker, although some lineages such as BRCA show a favorable association.

BLCA, SKCM, and LGG are the cancer types where HBG1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	III,IV	0.197	0.684	.013	6	view →
SKCM	DFS	Median	IV	0.040	0.454	.028	6	view →
LGG	DFS	Median	All	0.216	0.728	.022	3	view →
LUAD	OS	Median	All	0.276	0.697	.040	3	view →
BRCA	OS	Median	All	0.928	0.924	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: HBG1 tumor-vs-normal RNA expression · all HBG1 data types