Across TCGA pan-cancer cohorts, HBG1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated HBG1 data layer compared with 16 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher HBG1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated HBG1 expression acts as an unfavorable survival marker.

CCRCC, PDAC, and LSCC are the cancer types where HBG1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	II,III,IV	0.665	0.965	.011	13	view →
PDAC	DFS	Quartile	II,III,IV	0.299	0.590	.007	9	view →
LSCC	OS	Median	All	0.933	1.000	.015	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: HBG1 tumor-vs-normal RNA expression · all HBG1 data types