Across TCGA patient cohorts, HBG1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible HBG1-associated genes across cancer lineages are Fibronectin, RBM15, and HER2_pY1248. Each is linked with HBG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HBG1-to-partner and partner-to-HBG1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HBG1→partner) and Y-score (partner→HBG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Fibronectin →	-0.601	-3.000	.019	.035	3	1
SKCM	RBM15 →	+0.449	+3.000	.043	.036	3	1
SKCM	HER2_pY1248 →	-0.173	-3.000	.038	.036	1	1
SKCM	MEK1_p_S217_S221 →	-0.332	-3.000	.013	.036	1	1
SKCM	MSH2 →	+0.270	+3.017	.033	.019	1	1
SKCM	C-Raf_pS338 →	-0.163	-3.000	.023	.036	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

HBG1 survival (RNA) · tumor vs normal (RNA) · all HBG1 data types