Across TCGA patient cohorts, HBE1 mutation is significantly associated with the RNA expression of many other genes, with 503 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HBE1-associated genes across cancer lineages are CHAF1A, SHMT1, and NCAPH2. Each is linked with HBE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HBE1-to-partner and partner-to-HBE1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HBE1→partner) and Y-score (partner→HBE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHAF1A →	+0.581	+3.721	.008	<.001	3	2
UCEC	SHMT1 →	+0.654	+3.475	.002	.002	3	2
UCEC	NCAPH2 →	+0.596	+3.700	<.001	.001	3	2
CESC	LINC01177 →	+0.118	+6.144	<.001	.001	3	2
SKCM	LINC00674 →	+0.627	+2.706	.002	.003	3	2
UCEC	FOXM1 →	+0.880	+2.606	.008	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 503 associations by consensus.

Exploration

HBE1 survival (RNA) · tumor vs normal (RNA) · all HBE1 data types