Across TCGA patient cohorts, HBE1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HBE1-associated genes across cancer lineages are ACC_pS79, IRS1, and PCNA. Each is linked with HBE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HBE1-to-partner and partner-to-HBE1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HBE1→partner) and Y-score (partner→HBE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC_pS79 →	+0.462	+3.179	.005	.010	3	1
UCEC	IRS1 →	-0.248	-3.000	.013	.036	3	1
UCEC	PCNA →	+0.220	+3.000	.035	.036	3	1
UCEC	CDK1_pY15 →	+0.213	+2.829	.034	.035	3	1
UCEC	ACC1 →	+0.481	+2.459	.006	.020	2	1
UCEC	p90 RSK →	+0.185	+2.817	.045	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

HBE1 survival (RNA) · tumor vs normal (RNA) · all HBE1 data types