Across TCGA pan-cancer cohorts, HBD mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HBD data layer compared with 20 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher HBD mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HBD expression acts as an unfavorable survival marker, although some lineages such as COAD and CCRCC show a favorable association.

COAD, LUAD, and CCRCC are the cancer types where HBD mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	III,IV	1.000	0.746	.018	24	view →
LUAD	DFS	Tertile	All	0.811	0.997	.001	23	view →
CCRCC	DFS	Tertile	All	0.940	0.624	.001	20	view →
PDAC	OS	Median	III,IV	0.537	1.000	.008	5	view →
HNSC	DFS	Median	III,IV	0.988	0.916	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: HBD tumor-vs-normal RNA expression · all HBD data types