Across TCGA patient cohorts, HBD protein abundance is significantly associated with the RNA expression of many other genes, with 3,129 significant associations in total. OV shows the largest number of these associations.

The most reproducible HBD-associated genes across cancer lineages are HBB, HBA2, and HBA1. Each is linked with HBD in more than 9 cancer types. Because this analysis shows association rather than direction, both HBD-to-partner and partner-to-HBD results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HBD→partner) and Y-score (partner→HBD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	HBB →	+2.424	+0.986	<.001	<.001	3	10
OV	HBA2 →	+2.183	+1.154	<.001	<.001	3	9
GBM	HBA1 →	+1.845	+1.029	<.001	<.001	3	9
OV	FOSB →	+3.002	+1.146	<.001	<.001	3	6
CCRCC	HEMGN →	+0.577	+1.001	<.001	<.001	3	6
GBM	PF4 →	+0.950	+0.928	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,129 associations by consensus.

Exploration

HBD survival (RNA) · tumor vs normal (RNA) · all HBD data types