Across TCGA patient cohorts, HBD mutation is significantly associated with the RNA expression of many other genes, with 1,494 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HBD-associated genes across cancer lineages are SPRING1, OXSM, and PGM1. Each is linked with HBD in more than 2 cancer types. Because this analysis shows association rather than direction, both HBD-to-partner and partner-to-HBD results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HBD→partner) and Y-score (partner→HBD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SPRING1 →	+0.488	+2.331	.001	.003	3	3
SKCM	OXSM →	+0.330	+2.738	.001	.002	3	3
SKCM	PGM1 →	+0.700	+2.713	<.001	.003	3	3
SKCM	RPS6P20 →	+0.022	+1.838	.002	.001	3	3
UCEC	ADK →	+0.666	+3.364	.006	.005	2	3
SKCM	ANKRD9 →	+0.716	+2.857	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,494 associations by consensus.

Exploration

HBD survival (RNA) · tumor vs normal (RNA) · all HBD data types