Across TCGA patient cohorts, HBD mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HBD-associated genes across cancer lineages are 53BP1, Ku80, and ER-alpha_pS118. Each is linked with HBD in more than 1 cancer types. Because this analysis shows association rather than direction, both HBD-to-partner and partner-to-HBD results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HBD→partner) and Y-score (partner→HBD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	53BP1 →	+0.399	+2.179	.043	.035	3	2
SKCM	Ku80 →	-0.251	-1.807	.026	.026	3	2
LUSC	ER-alpha_pS118 →	+0.122	+2.215	.008	.032	3	1
LUSC	Bap1-c-4 →	+0.316	+2.179	.008	.035	3	1
LUSC	Bim →	+0.297	+2.179	.026	.035	3	1
LUSC	eEF2K →	+0.335	+2.179	.039	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Exploration

HBD survival (RNA) · tumor vs normal (RNA) · all HBD data types